Publications
As part of our commitment to defeat degeneration, Denali encourages active engagement with the broader scientific community.
Selected publications that reflect our distinct scientific approach are highlighted below.
Recent Publications
International Journal of Molecular Sciences, July 30, 2020
DOI 10.3390/ijms21155449
Junhua Wang, Akhil Bhalla, Julie C. Ullman, Meng Fang, Ritesh Ravi, Annie Arguello, Elliot Thomsen, Buyankhishig Tsogtbaatar, Jing L. Guo, Lukas L. Skuja, Jason C. Dugas, Sonnet S. Davis, Suresh B. Poda, Kannan Gunasekaran, Simona Costanzo, Zachary K. Sweeney, Anastasia G. Henry, Jeffrey M. Harris, Kirk R. Henne, Giuseppe Astarita
International Journal of Molecular Sciences, July 22, 2020
DOI 10.3390/ijms21155188
Akhil Bhalla, Ritesh Ravi, Meng Fang, Annie Arguello, Sonnet S. Davis, Chi-Lu Chiu, Jessica R. Blumenfeld, Hoang N. Nguyen, Timothy K. Earr, Junhua Wang, Giuseppe Astarita, Yuda Zhu, Damian Fiore, Kimberly Scearce-Levie, Dolores Diaz, Heather Cahan, Matthew D. Troyer, Jeffrey M. Harris, Maria L. Escolar
Nature, June 8, 2020
DOI 10.1038/s41593-020-0650-6
Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S. Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M. Monroe & Joseph W. Lewcock
Science Translational Medicine, May 27, 2020
DOI 10.1126/scitranslmed.aay1359
Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz, Wanda Kwan, Cathal S. Mahon, Raymond Tong, Do Jin Kim, Ankita Srivastava, Catherine Bedard, Kirk R. Henne, Tina Giese, Victoria A. Assimon, Xiaocheng Chen, Yin Zhang, Hilda Solanoy, Katherine Jenkins, Pascal E. Sanchez, Lesley Kane, Takashi Miyamoto, Kylie S. Chew, Michelle E. Pizzo, Nicholas Liang, Meredith E. K. Calvert, Sarah L. DeVos, Sulochanadevi Baskaran, Sejal Hall, Zachary K. Sweeney, Robert G. Thorne, Ryan J. Watts, Mark S. Dennis, Adam P. Silverman, Y. Joy Yu Zuchero
Science Translational Medicine, May 27, 2020
DOI 10.1126/scitranslmed.aay1163
Julie C. Ullman, Annie Arguello, Jennifer A. Getz, Akhil Bhalla, Cathal S. Mahon, Junhua Wang , Tina Giese , Catherine Bedard , Do Jin Kim , Jessica R. Blumenfeld, Nicholas Liang, Ritesh Ravi, Alicia A. Nugent, Sonnet S. Davis, Connie Ha, Joseph Duque, Hai L. Tran, Robert C. Wells, Steve Lianoglou, Vinay M. Daryani, Wanda Kwan, Hilda Solanoy, Hoang Nguyen, Timothy Earr, Jason C. Dugas, Michael D. Tuck, Jennifer L. Harvey, Michelle L. Reyzer, Richard M. Caprioli, Sejal Hall, Suresh Poda, Pascal E. Sanchez, Mark S. Dennis, Kannan Gunasekaran, Ankita Srivastava, Thomas Sandmann, Kirk R. Henne, Robert G. Thorne, Gilbert Di Paolo, Giuseppe Astarita, Dolores Diaz, Adam P. Silverman, Ryan J. Watts, Zachary K. Sweeney, Mihalis S. Kariolis, Anastasia G. Henry
Leveraging preclinical models for the development of Alzheimer disease therapeutics
Nature Reviews Drug Discovery, April 8, 2020
DOI 10.1038/s41573-020-0065-9
Kimberly Scearce-Levie, Pascal E. Sanchez, Joseph W. Lewcock
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
EMBO Mol Medicine, March 10, 2020
DOI 10.15252/emmm.201911227
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, and Christian Haass
Review: Cell Death and Neurodegeneration
Cold Spring Harbor Perspectives, February 3, 2020
DOI 10.1101/cshperspect.a036434
Benjamin J. Andreone, Martin Larhammar, Joseph W. Lewcock
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Neuron, January 2, 2020
DOI 10.1016/j.neuron.2019.12.007
Alicia A. Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S. Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C.G. Haddick, Melina Lenser, Timothy K. Earr, Ju Shi, Jason C. Dugas, Benjamin J. Andreone, Todd Logan, Hilda O. Solanoy, Hang Chen 5, Ankita Srivastava, Suresh B. Poda, Pascal E. Sanchez, Ryan J. Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W. Lewcock, Kathryn M. Monroe, Gilbert Di Paolo
Clinical Pharmacology & Therapeutics, August 22, 2019
DOI 10.1002/cpt.1615
Hendrika W. Grievink, Jules A.A.C. Heuberger, Fen Huang, Rinkal Chaudhary, Willem A.J. Birkhoff, George R. Tonn, Sofia Mosesova, Rebecca Erickson, Matthijs Moerland, Patrick C.G. Haddick, Kimberly Scearce‐Levie, Carole Ho, Geert Jan Groeneveld
Neuron, July 1, 2019
DOI 10.1016/j.neuron.2019.05.048
Mark Y. Fang, Sebastian Markmiller, Anthony Q. Vu, Ashkan Javaherian, William E. Dowdle, Philippe Jolivet, Paul J. Bushway, Nicholas A. Castello, Ashmita Baral, Michelle Y. Chan, Jeremy W. Linsley, Drew Linsley, Mark Mercola, Steven Finkbeiner, Eric Lecuyer, Joseph W. Lewcock, Gene W. Yeo
SUPT4H1 Depletion Leads to a Global Reduction in RNA
Cell Reports, January 2, 2019
DOI 10.1016/j.celrep.2018.12.004
Adam Naguib, Thomas Sandmann, Fei Yi, Ryan J Watts, Joseph W Lewcock, William E Dowdle
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
The Journal of Clinical Investigation, March 30, 2018
DOI 10.1172/jci96429
Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Adam P Silverman, Jing L Guo, Jennifer Getz, Kirk Henne, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, Patrick M Sullivan, Eli Paul Lerner, Eloise Hudry, Zachary K Sweeney, Mark S Dennis, Bradley T Hyman, Ryan J Watts, David M Holtzman