Committee Composition

Name

Audit

Compensation

Corporate Governance & Nominating

Science & Technology

ETV:ARSA

Arylsulfatase A (ARSA) is an enzyme responsible for breaking down sulfatides within lysosomes. Genetic variants in ARSA result in a reduction of lysosomal ARSA enzymatic activity and cause Metachromatic Leukodystrophy (MLD). MLD is characterized by an accumulation of sulfatides leading to neuronal degradation resulting in progressive cognitive and motor decline. ETV:ARSA is a recombinant ARSA enzyme engineered to cross the blood-brain barrier and to replace ARSA to treat neuropathic and systemic manifestations of the disease.

Disease Indications
MLD
Program Targets
Arylsulfitase A
Development Stage
Drug Discovery
Molecule Size
Large Molecule
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Chairperson

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Member

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Chairperson of the Board

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Oncology

ATV:HER2

Program Target

HER2

Development Stage

Drug Discovery